

In cosmetic applications, botulinum toxin is considered safe and effective for reduction of facial wrinkles, especially in the uppermost third of the face.[37] Commercial forms are marketed under the brand names Botox Cosmetic/Vistabel from Allergan, Dysport/Azzalure from Galderma and Ipsen, Xeomin/Bocouture from Merz, and in the U.S. only, Jeuveau from Evolus, manufactured by Daewoong.[13] The effects of current botulinum toxin injections for glabellar lines (’11’s lines’ between the eyes) typically last two to four months and in some cases, product-dependent, with some patients experiencing a longer duration of effect.[37] Injection of botulinum toxin into the muscles under facial wrinkles causes relaxation of those muscles, resulting in the smoothing of the overlying skin.[37] Smoothing of wrinkles is usually visible three to five days after injection, with maximum effect typically a week following injection.[37] Muscles can be treated repeatedly to maintain the smoothed appearance.
websource: https://en.wikipedia.org/wiki/Botulinum_toxin
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